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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - 653-47 hydrochloride

653-47 hydrochloride

CAS No. 1224567-46-7

653-47 hydrochloride( —— )

Catalog No. M23394 CAS No. 1224567-46-7

653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 335 In Stock
25MG 566 In Stock
50MG 806 In Stock
100MG 1098 In Stock
500MG 2205 In Stock
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Biological Information

  • Product Name
    653-47 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15.?
  • Description
    653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15.?It is also a very weak CREB inhibitor with IC50 of 26.3 μM.
  • In Vitro
    653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    CREB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1224567-46-7
  • Formula Weight
    407.29
  • Molecular Formula
    C20H20Cl2N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL?(613.81 mM;?Need ultrasonic)
  • SMILES
    O=C(NC1=CC=C(C=C1O)Cl)C2=C(C=C3C=CC=CC3=C2)OCCCN.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
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